反应详情

温度

0 °C

A suspension containing 4 g (16.12 mmoles) of 6-phenyl-1,4,5,6-tetrahydro-2-pyrimidinamine hydrochloride (1:2), 3.11 g (16.12 mmoles) of ethyl 3-(pyridin-4-yl)-3-oxopropionate, 6.68 g (48.36 mmoles) of anhydrous potassium carbonate in 50 ml of ethanol were refluxed for 18 h. The cooled solution was evaporated and the residue was treated with water and allowed to stir at 0° C. during 2 h. The precipitate which formed was recovered by filtration and dried at 90° C. during 18 h. 4.80 g (98%) of product was thus obtained.

1. temperaturewere refluxed for 18 h
2. customThe cooled solution was evaporated
3. additionthe residue was treated with water
4. customThe precipitate which formed
5. filtrationwas recovered by filtration
6. customdried at 90° C. during 18 h