Hydrochloric Acid → HCID 69470282, compound

HRID 1296527Notes

Reaction equation

HRID 1296527 reaction equation
O.[NH:2]1[C:6]([CH2:7][CH2:8][CH:9]2[CH2:18][CH2:17][CH:16]3[CH:11]([CH2:12][CH:13]([C:19]([OH:21])=[O:20])[NH:14][CH2:15]3)[CH2:10]2)=[N:5][N:4]=[N:3]1.Cl.[CH2:23](O)[CH3:24]>>[CH2:23]([O:20][C:19]([CH:13]1[CH2:12][CH:11]2[CH:16]([CH2:17][CH2:18][CH:9]([CH2:8][CH2:7][C:6]3[N:5]=[N:4][NH:3][N:2]=3)[CH2:10]2)[CH2:15][NH:14]1)=[O:21])[CH3:24]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178526951HCID 178526951, compound

Product 1

HCID 69470282HCID 69470282, compoundYield 100%

Procedure

A solution of 6.0 g (21.5 mmol) of 6-[2-(1H-Tetrazol-5-yl)-ethyl]-decahydro-isoquinoline-3-carboxylic acid monohydrate in 70 mL of ethanol saturated with hydrogen chloride (g) is heated at reflux overnight. The mixture is concentrated in vacuo, suspended in diethyl ether, and again concentrated in vacuo. The residue is suspended in diethyl ether and heated at reflux for 3 hr. The solid is filtered and rinsed with diethyl ether to afford 7.4 g (100%) of the title compound.

Workup

  1. temperatureat reflux overnight
  2. concentrationThe mixture is concentrated in vacuo
  3. concentrationagain concentrated in vacuo
  4. temperatureheated
  5. temperatureat reflux for 3 hr
  6. filtrationThe solid is filtered
  7. washrinsed with diethyl ether

Sources & evidence

ORD record
ord-196422547bfc4a0583c28792c755ed56
Source dataset
uspto-grants-2007_07
Patent number
US07247644B2

Reaction notes

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