Methanol → HCID 19372152, compound

HRID 129655Notes

Reaction equation

HRID 129655 reaction equation
S(Cl)([Cl:3])=O.[NH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23].[CH3:25]O>>[ClH:3].[NH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([O:24][CH3:25])=[O:23]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 21063702HCID 21063702, compound

Product 1

HCID 19372152HCID 19372152, compound

Conditions

Temperature
-20 °C

Procedure

0.37 cm3 of thionyl chloride are added to 23 cm3 of methanol cooled to -20° C. and 980 mg of 17-aminoheptadecanoic acid are added. The solution is stirred for 12 hours at a temperature in the region of 20° C. and the solvent is removed under reduced pressure (2.7 kPa) at a temperature in the region of 40° C. 1.08 g of methyl 17-aminoheptadecanoate hydrochloride are thus obtained in the form of a white solid.

Workup

  1. customthe solvent is removed under reduced pressure (2.7 kPa) at a temperature in the region of 40° C

Sources & evidence

ORD record
ord-59e3ea71b3dd4ed2bb6e4b8a81529280
Source dataset
uspto-grants-1995_11
Patent number
US05468888

Reaction notes

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