Hydrazine hydrate (1:1) → HCID 21063702, compound

HRID 129656Notes

Reaction equation

HRID 129656 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23])C(=O)C2=CC=CC=C12.O.NN>CO>[NH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19372059HCID 19372059, compound

Product 1

HCID 21063702HCID 21063702, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

A solution of 3.4 g of 17-phthalimidoheptadecanoic acid in 60 cm3 of methanol is stirred for 1 hour, at a temperature in the region of 80° C., in the presence of 1.67 g of hydrazine hydrate. The solution is cooled to around 20° C. and the solid is separated by filtration and dried in air. The residue (1.92 g) is taken up in 180 cm3 of distilled water. The solid is separated by filtration, washed with a total of 45 cm3 of distilled water and dried under reduced pressure (13.5 Pa) at a temperature in the region of 40° C. 980 mg of 17-aminoheptadecanoic acid are obtained in the form of a white solid.

Workup

  1. customthe solid is separated by filtration
  2. customdried in air
  3. customThe solid is separated by filtration
  4. washwashed with a total of 45 cm3 of distilled water
  5. customdried under reduced pressure (13.5 Pa) at a temperature in the region of 40° C

Sources & evidence

ORD record
ord-b19feb93099e479a99208f0e33fbe6d6
Source dataset
uspto-grants-1995_11
Patent number
US05468888

Reaction notes

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