(1,1'-Biphenyl)-4-methanol → HCID 18186833, compound

HRID 1296612Notes

Reaction equation

HRID 1296612 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[C:9]1([C:15]2[CH:22]=[CH:21][C:18]([CH2:19][OH:20])=[CH:17][CH:16]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[H-].[Na+]>>[C:15]1([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:16]=[CH:17][C:18]([CH2:19][O:20][C:2]2[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=2)=[CH:21][CH:22]=1

Participants

4

Reactant 3

HCID 19186(1,1'-Biphenyl)-4-methanolHCID 24758Sodium hydrideHCID 785042,6-Dichloropyrazine

Product 1

HCID 18186833HCID 18186833, compoundYield 88%

Procedure

The title compound was prepared according to the procedure of example 4, step 1 starting from 2,6-dichloropyrazine (444 mg, 3.00 mmol), p-phenylbenzyl alcohol (607 mg, 3.30 mmol) and NaH (55% in mineral oil, 144 mg, 3.30 mmol). Recrystallization from hexane gave 0.55 g (88%) of the title compound: mp 86-87° C. MS m/z: 297 (M+H)+. Anal. (C17H13ClN2O) C, H, N.

Workup

  1. customThe title compound was prepared
  2. customRecrystallization from hexane

Sources & evidence

ORD record
ord-47e88dc56cd5418ca6d669b4eb9d574e
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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