3-Pyridinemethanol → HCID 18186796, compound

HRID 1296616Notes

Reaction equation

HRID 1296616 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[CH:9]1[CH:14]=[N:13][CH:12]=[C:11]([CH2:15][OH:16])[CH:10]=1.[H-].[Na+]>O1CCOCC1>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:16][CH2:15][C:11]2[CH:12]=[N:13][CH:14]=[CH:9][CH:10]=2)[N:3]=1

Participants

5

Reactant 3

HCID 75103-PyridinemethanolHCID 24758Sodium hydrideHCID 785042,6-Dichloropyrazine

Product 1

HCID 18186796HCID 18186796, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared according to the procedure of example 4, step 1 starting from 2,6-dichloropyrazine (444 mg, 3.00 mmol), nicotinic alcohol (360 mg, 3.30 mmol) in dioxane (5 mL) and NaH (55% in oil, 144 mg, 3.30 mmol). The crude product, obtained as an oil (0.72 g), was used directly in the next step. MS m/z 221 (M)+.

Sources & evidence

ORD record
ord-b251cf51141e469eb482ab2a11c45258
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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