Dichloromethane → HCID 18186880, compound

HRID 1296649Notes

Reaction equation

HRID 1296649 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]([OH:11])[CH3:10].[Cl:12][C:13]1[CH:18]=[N:17][CH:16]=[C:15](Cl)[N:14]=1.ClCCl.C([O-])([O-])=O.[K+].[K+]>O1CCOCC1>[Cl:12][C:13]1[CH:18]=[N:17][CH:16]=[C:15]([O:11][CH:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[CH3:10])[N:14]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 785042,6-DichloropyrazineHCID 1145381-(2-Methoxyphenyl)ethan-1-ol

Product 1

HCID 18186880HCID 18186880, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

K-t-BuO (0.67 g, 5.97 mmol) was added to a stirred solution of 1-(2-methoxyphenyl)ethanol (0.96 g, 6.28 mmol) in dioxane (15 mL) at 0° C. (ice-bath). After 5 min of stirring at room temperature, the reaction mixture was chilled to 0° C. (ice-bath) and 2,6-dichloropyrazine (0.78 g, 5.23 mmol) was added whereupon the reaction mixture turned yellow. After being stirrred for 35 min, dichloromethane and K2CO3 were added and the mixture was filtered. Concentration in vacuo furnished a yellow oil that was purified by silica gel chromatography (15×4 cm) using n-hexane ethyl acetate (8:2) as eluent. This gave 1.21 g (92%) of the title compound as a colorless oil. HRMS m/z calcd for C13H13ClN2O2 (M)+ 264.0666, found 264.0677. Anal. (C13H13ClN2O2) C, H, N.

Workup

  1. additionwas added whereupon the reaction mixture
  2. waitAfter being stirrred for 35 min
  3. filtrationthe mixture was filtered
  4. concentrationConcentration in vacuo
  5. customfurnished a yellow oil that
  6. customwas purified by silica gel chromatography (15×4 cm)

Sources & evidence

ORD record
ord-1439f73867724ad0919ab3a35b175450
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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