Benzyl Alcohol → HCID 68574778, compound

HRID 1296652Notes

Reaction equation

HRID 1296652 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][C@@H:12]([CH3:14])[NH:11][CH2:10][C@@H:9]2[CH3:15])[CH:5]=[N:4][CH:3]=1.[CH2:16]([OH:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([O:23][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][C@@H:12]([CH3:14])[NH:11][CH2:10][C@@H:9]2[CH3:15])[CH:5]=[N:4][CH:3]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 244Benzyl AlcoholHCID 86759067HCID 86759067, compound

Product 1

HCID 68574778HCID 68574778, compound

Conditions

Temperature
95 °C

Procedure

The title compound was prepared according to the procedure of example 20, starting from 1-(6-chloro-2-pyrazinyl)-trans-2,5-dimethylpiperazine (1.23 g, 5.40 mmol; obtained in step 1 above), benzyl alcohol (8.36 g, 77.3 mmol), and K-t-BuO (1.99 g, 17.7 mmol). The reaction mixture was heated at 95° C. for 5.5 h. The yield of the title compound was 0.47 g (29%) which was obtained as an oil. Purity 99% (HPLC). MS m/z 298 (M)+. HRMS m/z calcd for C17H22N4O (M)+ 298.1794, found 298.1798.

Workup

  1. customThe title compound was prepared
  2. customwas obtained as an oil

Sources & evidence

ORD record
ord-551989a8b3184690aae338f33255a665
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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