Benzyl Alcohol → HCID 68574778, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared according to the procedure of example 20, starting from 1-(6-chloro-2-pyrazinyl)-trans-2,5-dimethylpiperazine (1.23 g, 5.40 mmol; obtained in step 1 above), benzyl alcohol (8.36 g, 77.3 mmol), and K-t-BuO (1.99 g, 17.7 mmol). The reaction mixture was heated at 95° C. for 5.5 h. The yield of the title compound was 0.47 g (29%) which was obtained as an oil. Purity 99% (HPLC). MS m/z 298 (M)+. HRMS m/z calcd for C17H22N4O (M)+ 298.1794, found 298.1798.

Provenance & Evidence