3-(Phenylmethoxy)benzenemethanol → 2-{[3-(Benzyloxy)Benzyl]Oxy}-6-Chloropyrazine

HRID 1296661Notes

Reaction equation

HRID 1296661 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][OH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:23]=[N:22][CH:21]=[C:20](Cl)[N:19]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][O:13][C:20]1[CH:21]=[N:22][CH:23]=[C:18]([Cl:17])[N:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 743413-(Phenylmethoxy)benzenemethanolHCID 785042,6-Dichloropyrazine

Product 1

HCID 181869282-{[3-(Benzyloxy)Benzyl]Oxy}-6-Chloropyrazine

Procedure

The title compound was prepared according to the procedure of example 50, step 1, starting from 3-benzyloxybenzyl alcohol (3.46 g, 16.2 mmol), K-t-BuO (1.69 g, 15.1 mmol) and 2,6-dichloropyrazine (1.97 g, 13.2 mmol). The yield of the title compound was 2.64 g (61%) and was obtained as a semisolid. Anal. (C18H15ClN2O2) C, H, N.

Workup

  1. customThe title compound was prepared
  2. customwas obtained as a semisolid

Sources & evidence

ORD record
ord-6e319fc23b8242ebbb02d78b53566780
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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