Benzoic Acid → 2-(2-(Benzamidomethyl)-5-carbamimidoylphenylamino)acetic acid

HRID 1296768Notes

Reaction equation

HRID 1296768 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]=C(C)O[N:11]=2)=[CH:6][C:5]=1[NH:16][CH2:17][C:18]([O:20]CC1C=CC=CC=1)=[O:19].[C:28](O)(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[C:28]([NH:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[NH:11])[NH2:14])=[CH:6][C:5]=1[NH:16][CH2:17][C:18]([OH:20])=[O:19])(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 243Benzoic AcidHCID 69490392Benzyl 2-(2-(aminomethyl)-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenylamino)acetate hydrochloride

Product 1

HCID 113018252-(2-(Benzamidomethyl)-5-carbamimidoylphenylamino)acetic acid

Procedure

Compound 58d was reacted with benzoic acid and subsequently hydrogenated according to the the procedure described in Example 58, to give Example 62. ESI-MS m/e 327.5 (M+1).

Workup

  1. customto give Example 62

Sources & evidence

ORD record
ord-35a8daa004d34cc49b6b730574e02279
Source dataset
uspto-grants-2007_07
Patent number
US07247654B2

Reaction notes

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