3-Methoxybenzoic Acid → 2-(5-Carbamimidoyl-2-((3-methoxybenzamido)methyl)phenylamino)acetic acid

HRID 1296775Notes

Reaction equation

HRID 1296775 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]=C(C)O[N:11]=2)=[CH:6][C:5]=1[NH:16][CH2:17][C:18]([O:20]CC1C=CC=CC=1)=[O:19].[C:28](O)(=[O:37])[C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=1>>[C:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][NH:2][C:28](=[O:37])[C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=2)=[C:5]([NH:16][CH2:17][C:18]([OH:20])=[O:19])[CH:6]=1)(=[NH:11])[NH2:14]

Participants

3

Reactant 2

HCID 114613-Methoxybenzoic AcidHCID 69490392Benzyl 2-(2-(aminomethyl)-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenylamino)acetate hydrochloride

Product 1

HCID 113602692-(5-Carbamimidoyl-2-((3-methoxybenzamido)methyl)phenylamino)acetic acid

Procedure

Compound 58d was reacted with m-anisic acid and subsequently hydrogenated according to the procedure described in Example 58, to give example 66. ESI-MS m/e 357.5 (M+1).

Workup

  1. customto give example 66

Sources & evidence

ORD record
ord-897a877a240b47efb80d9e53742ab83f
Source dataset
uspto-grants-2007_07
Patent number
US07247654B2

Reaction notes

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