1-Phenyl-2-(piperidin-1-yl)ethane-1,2-dione → 7-Phenyl-1-azabicyclo[4.2.0]octan-8-one

HRID 1296783Notes

Reaction equation

HRID 1296783 reaction equation
[C:1]1([C:7](=O)[C:8]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O>[C:1]1([CH:7]2[C:8](=[O:9])[N:10]3[CH:15]2[CH2:14][CH2:13][CH2:12][CH2:11]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 109659651-Phenyl-2-(piperidin-1-yl)ethane-1,2-dione

Product 1

HCID 123162767-Phenyl-1-azabicyclo[4.2.0]octan-8-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

contacting a solution of 1-(phenylglyoxylyl)piperidine arenesulfonylhydrazone in a water immiscible organic solvent with an inorganic base, in the presence of phase transfer catalyst to obtain 7-phenyl-1-azabicyclo[4.2.0]octan-8-one;

Sources & evidence

ORD record
ord-c0817e1b17ed4a118cccec7145fd8618
Source dataset
uspto-grants-2007_07
Patent number
US07247730B2

Reaction notes

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