Hydrochloric Acid → Methylphenidate

HRID 1296788Notes

Reaction equation

HRID 1296788 reaction equation
Cl.[C:2]1([CH:8]2[C:15](=[O:16])[N:14]3[CH:9]2[CH2:10][CH2:11][CH2:12][CH2:13]3)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][OH:18]>>[CH3:17][O:18][C:15]([CH:8]([CH:9]1[NH:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:16]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 123162767-Phenyl-1-azabicyclo[4.2.0]octan-8-one

Product 1

HCID 4158MethylphenidateYield 76.9%

Conditions

Temperature
50 °C

Procedure

Hydrogen chloride (gas) was passed through a stirred solution of 7-phenyl-1-azabicyclo[4.2.0]octan-8-one with R*R*/S*R* 3.3:1 by GC (2.61 Kg, 13.0 mol) in methanol (13 L) under reflux conditions for 60 hour until TLC indicated that all starting material had been consumed. The mixture was evaporated under reduced pressure. The residue was treated with hot water (8 L) for 0.5 h. The hot mixture was filtered, cooled to 50° C., washed with toluene (2×1.2 L), cooled to the room temperature, basified with sodium carbonate to pH 10-11 and extracted with dichloromethane (3×2.5 L). The combined organic extracts were dried over sodium sulfate, filtered and evaporated under reduced pressure to give 2.33 Kg (76.9%) of methylphenidate with threolerythro 3.5:1 by GC.

Workup

  1. customhad been consumed
  2. customThe mixture was evaporated under reduced pressure
  3. additionThe residue was treated with hot water (8 L) for 0.5 h
  4. filtrationThe hot mixture was filtered
  5. washwashed with toluene (2×1.2 L)
  6. temperaturecooled to the room temperature
  7. extractionextracted with dichloromethane (3×2.5 L)
  8. dry with materialThe combined organic extracts were dried over sodium sulfate
  9. filtrationfiltered
  10. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-866731fb44f546ef84745dea1622af8e
Source dataset
uspto-grants-2007_07
Patent number
US07247730B2

Reaction notes

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