反应详情

The suspension of 1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (example 1b, 200 mg, 1.4 mmol), pseudothiohydantoin (159 mg, 1.4 mmol), and sodium acetate (459 mg, 5.6 mmol) in acetic acid (2 mL) was stirred under reflux for 12 h. After cooling to room temperature, water was added. The solid was collected by filtration, washed with water and dried to obtain 2-amino-5-[1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-meth-(Z)-ylidene]-thiazol-4-one (280 mg, 82%) as a slight yellow solid. LC-MS m/e 245 (MH+).

1. temperatureunder reflux for 12 h
2. filtrationThe solid was collected by filtration
3. washwashed with water
4. customdried