Water → HCID 178508970, compound

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Sodium Acetate	HCID 517045	—
Reactant	1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde	HCID 5372812	—
Reactant	(5Z)-5-[(3-cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one	HCID 137629131	—
Solvent	Acetic Acid	HCID 176	—
Product	HCID 178508970	HCID 178508970	82%

Reaction Steps

The suspension of 1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (example 1b, 200 mg, 1.4 mmol), pseudothiohydantoin (159 mg, 1.4 mmol), and sodium acetate (459 mg, 5.6 mmol) in acetic acid (2 mL) was stirred under reflux for 12 h. After cooling to room temperature, water was added. The solid was collected by filtration, washed with water and dried to obtain 2-amino-5-[1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-meth-(Z)-ylidene]-thiazol-4-one (280 mg, 82%) as a slight yellow solid. LC-MS m/e 245 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07247727B2
Source dataset	uspto-grants-2007_07
ORD ID	ord-8933953e4a4646c7b6a978d023ae779c
Source note	uspto-grants-2007_07