HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Cinacalcet Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cinacalcet | HCID 156419 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Cinacalcet Hydrochloride | HCID 156418 | 95.3% |
Reaction Steps
2.0 grams of cinacalcet base was dissolved in acetone (10 ml). Then HCl gas (0.3 g; 1.5 eq.) was bubbled into the solution. The obtained solution was evaporated under reduced pressure until dryness to obtain 2.1 g of cinacalcet hydrochloride crystalline Form I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07247751B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-36d2ead6aa7143d1bcbc31366cdd359f |
| Source note | uspto-grants-2007_07 |