Hydrochloric Acid → Cinacalcet Hydrochloride

HRID 1296836Notes

Reaction equation

HRID 1296836 reaction equation
[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]>CC(C)=O>[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 156419Cinacalcet

Product 1

HCID 156418Cinacalcet HydrochlorideYield 95.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2.0 grams of cinacalcet base was dissolved in acetone (10 ml). Then HCl gas (0.3 g; 1.5 eq.) was bubbled into the solution. The obtained solution was evaporated under reduced pressure until dryness to obtain 2.1 g of cinacalcet hydrochloride crystalline Form I.

Workup

  1. customThe obtained solution was evaporated under reduced pressure until dryness

Sources & evidence

ORD record
ord-36d2ead6aa7143d1bcbc31366cdd359f
Source dataset
uspto-grants-2007_07
Patent number
US07247751B2

Reaction notes

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