Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

Cinacalcet base (2.0 g) was dissolved in acetone (4 ml) at room temperature. Then 1N HCl (1.5 eq.) and water (40 ml) were added to the solution. The resulting mixture was stirred at room temperature for 4 hours to obtain a precipitate. The product was isolated by filtration, washed with water (10 ml) and dried at 50° C. in a vacuum oven for 24 hours to obtain 1.75 g of cinacalcet hydrochloride crystalline Form I.

Provenance & Evidence