Hydrochloric Acid → Cinacalcet Hydrochloride

HRID 1296837Notes

Reaction equation

HRID 1296837 reaction equation
[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27].O>CC(C)=O>[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 156419Cinacalcet

Product 1

HCID 156418Cinacalcet Hydrochloride

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Cinacalcet base (2.0 g) was dissolved in acetone (4 ml) at room temperature. Then 1N HCl (1.5 eq.) and water (40 ml) were added to the solution. The resulting mixture was stirred at room temperature for 4 hours to obtain a precipitate. The product was isolated by filtration, washed with water (10 ml) and dried at 50° C. in a vacuum oven for 24 hours to obtain 1.75 g of cinacalcet hydrochloride crystalline Form I.

Workup

  1. customto obtain a precipitate
  2. customThe product was isolated by filtration
  3. washwashed with water (10 ml)
  4. customdried at 50° C. in a vacuum oven for 24 hours

Sources & evidence

ORD record
ord-6f59bd95888a4ec7a694500d86eee966
Source dataset
uspto-grants-2007_07
Patent number
US07247751B2

Reaction notes

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