反应详情

0.3 g of cinacalcet base was dissolved in 4 ml of isobutyl acetate at room temperature, i.e., about 20° to about 25° C. Then, 2 ml of 1N HCl were added in one portion, and the mixture was stirred at room temperature overnight, yielding a precipitate. The product was isolated by filtration, washed with 5 ml of isobutyl acetate, and dried at 50° C. in a vacuum oven for 24 hours, yielding 0.12 g of cinacalcet hydrochloride crystalline Form I.

1. customi.e., about 20° to about 25° C
2. customyielding a precipitate
3. customThe product was isolated by filtration
4. washwashed with 5 ml of isobutyl acetate
5. customdried at 50° C. in a vacuum oven for 24 hours