Sodium borohydride → [4-(4-Ethylpiperazin-1-yl)phenyl]methanol

HRID 1296851Notes

Reaction equation

HRID 1296851 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[BH4-].[Na+]>C(O)C>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:16]=[CH:15][C:12]([CH2:13][OH:14])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 105130244-(4-ethylpiperazin-1-yl)benzaldehyde

Product 1

HCID 23514389[4-(4-Ethylpiperazin-1-yl)phenyl]methanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared in the manner of Step A, Example 5, using 0.4 gram (0.019 mole) of [4-(4-ethylpiperazinyl)benzaldehyde and 0.4 gram (0.01 mole) of sodium borohydride in 40 mL of absolute ethanol (available from J. T. Baker Inc.) The yield of the title compound was 0.3 gram. The NMR Spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in the manner of Step A, Example 5

Sources & evidence

ORD record
ord-814abed4cdbf46feb4e3a1da0b1f7214
Source dataset
uspto-grants-2007_07
Patent number
US07247756B2

Reaction notes

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