Phenylacetic Acid → 1-(5-Chloro-2,4-dihydroxyphenyl)-2-phenylethan-1-one

Participants

Reaction Steps

This compounds was synthesised in the same manner as described above. Phenylacetic acid (4.71 g, 34.6 mmol), 4-chlororesorcinol (5 g, 34.6 mmol), boron trifloride etherate (30 ml). After standing for two hours an orange precipitate formed. This was purified by flash chromatography to give the required compound as a white solid (7.2 g, 79.3%); Rf 0.9 hexane/ethyl acetate (20/80)].

Provenance & Evidence