4-Chlororesorcinol → HCID 58913651, compound

HRID 1296862Notes

Reaction equation

HRID 1296862 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:19]=[CH:18][C:16]([OH:17])=[CH:15][C:14]=1[OH:20]>B(F)(F)F.CCOCC>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([C:18]2[CH:19]=[C:13]([Cl:12])[C:14]([OH:20])=[CH:15][C:16]=2[OH:17])=[O:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 17314-ChlororesorcinolHCID 74654Benzeneacetic acid, 4-bromo-

Product 1

HCID 58913651HCID 58913651, compound

Reagents, catalysts & solvents 1

HCID 8000Boron trifluoride etherateSolvent

Procedure

This compounds was synthesised in the same manner as described above. 4-Bromophenylacetic acid (7.44 g, 34.6 mmol), 4-chlororesorcinol (5 g, 34.6 mmol), boron trifloride etherate (30 ml). After standing for two hours an orange precipitate formed. This was purified by flash chromatography to give the required compound as an off white solid (10.5 g, 89%); Rf 0.9 hexane/ethyl acetate (20/80).

Workup

  1. customThis compounds was synthesised in the same manner
  2. customan orange precipitate formed
  3. customThis was purified by flash chromatography

Sources & evidence

ORD record
ord-8086466511624d0e8bbd6292a7e332ed
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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