Acetic Anhydride → HCID 58913613, compound

HRID 1296870Notes

Reaction equation

[Cl:1][C:2]1[C:3]([OH:22])=[CH:4][C:5]([OH:21])=[C:6]([C:8](=[O:20])[CH2:9][C:10]2[CH:19]=[CH:18][C:13]3[O:14][CH2:15][CH2:16][O:17][C:12]=3[CH:11]=2)[CH:7]=1.[C:23](OC(=O)C)(=O)[CH3:24].C(=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][C:3]=1[OH:22])[O:21][C:23]([CH3:24])=[C:9]([C:10]1[CH:19]=[CH:18][C:13]3[O:14][CH2:15][CH2:16][O:17][C:12]=3[CH:11]=1)[C:8]2=[O:20]

Participants

Reactant 3

HCID 7918Acetic Anhydride

HCID 11430Potassium Carbonate

HCID 58913563HCID 58913563, compound

Product 1

HCID 58913613HCID 58913613, compound

Procedure

This compounds was synthesised in the same manner as described above. 1-(5-Chloro-2,4-dihydroxy-phenyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethanone (1.1.2.5) (0.3 g, 0.9 mmol), acetic anhydride (0.5 ml), potassium carbonate (0.5 g 3.6 mmol). 6-Chloro-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-7-hydroxy-2-methyl-chromen-4-one was obtained an off white solid (0.3 g, 96.8%).

Workup

customThis compounds was synthesised in the same manner

Sources & evidence

ORD record: ord-16b81a4c944e47409e6015d20a0358e1
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07247734B2

Reaction notes

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