Acetic Anhydride → HCID 58913571, compound

HRID 1296871Notes

Reaction equation

HRID 1296871 reaction equation
[Cl:1][C:2]1[C:3]([OH:24])=[CH:4][C:5]([OH:23])=[C:6]([C:8](=[O:22])[CH2:9][C:10]2[CH:21]=[CH:20][C:13]([O:14][CH2:15][CH2:16][CH2:17][C:18]#[N:19])=[CH:12][CH:11]=2)[CH:7]=1.[C:25](OC(=O)C)(=O)[CH3:26].C(=O)([O-])[O-].[K+].[K+]>CCCCCC.C(OCC)(=O)C>[Cl:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][C:3]=1[OH:24])[O:23][C:25]([CH3:26])=[C:9]([C:10]1[CH:21]=[CH:20][C:13]([O:14][CH2:15][CH2:16][CH2:17][C:18]#[N:19])=[CH:12][CH:11]=1)[C:8]2=[O:22]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 58913524HCID 58913524, compound

Product 1

HCID 58913571HCID 58913571, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

This compounds was synthesised in the same manner as described above. 4-{4-[2-(5-Chloro-2,4-dihydroxy-phenyl)-2-oxo-ethyl]-phenoxy}-butyronitrile (0.62 g, 1.8 mmol), acetic anhydride (1.0 ml), potassium carbonate (1 g, 7.2 mmol). 4-[4-(6-Chloro-7-hydroxy-2-methyl-4-oxo-4H-chromen-3-yl)-phenoxy]-butyronitrile was obtained as a white solid (0.55 g, 82.7%) Rf 0.6 ethyl acetate/hexane (70/30).

Workup

  1. customThis compounds was synthesised in the same manner

Sources & evidence

ORD record
ord-90d994df46e94dc2b7baebcaa921441f
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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