4-Chlororesorcinol → HCID 58913641, compound

Participants

Reaction Steps

This compounds was synthesised in the same manner as described above. 4-Chlororesorcinol (0.36 g, 2.5 mmol), [3-(2-Fluoro-ethoxy)-phenyl]-acetic acid (0.5 g, 2.5 mmol), BF3Et2O (5 ml), PCl5 (0.79 g, 3.79 mmol), DMF (8 ml and 5 ml). 6-Chloro-3-[3-(2-fluoro-ethoxy)-phenyl]-7-hydroxy-chromen-4-one precipitated out as a white solid (0.49 g, 58.6%). This was taken onto the next stage without further purification. Rf 0.6 ethyl acetate/hexane (70/30)].

Provenance & Evidence