Hydrazine hydrate (1:1) → HCID 178488792, compound

HRID 1296897Notes

Reaction equation

HRID 1296897 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:20](=O)[C:19]3[C:14](=[CH:15][C:16]([OH:22])=[CH:17][CH:18]=3)[O:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].O.[NH2:24][NH2:25]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:20]([C:19]3[CH:18]=[CH:17][C:16]([OH:22])=[CH:15][C:14]=3[OH:13])=[N:24][NH:25][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 5748605Cladrin

Product 1

HCID 178488792HCID 178488792, compoundYield 55.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compounds was synthesised in the same manner as described above. 3-(3,4-Dimethoxy-phenyl)-7-hydroxy-chromen-4-one (0.5 g, 1.68 mmol), hydrazine hydrate (4 ml), ethanol (10 ml). The crude product was columned to give 4-[4-(3,4-Dimethoxy-phenyl)-1H-pyrazol-3-yl]-benzene-1,3-diol as a pale yellow solid (0.29 g, 55.3%); Rf 0.2 Cf SM 0.7 ethyl acetate/hexane (75/25).

Workup

  1. customThis compounds was synthesised in the same manner

Sources & evidence

ORD record
ord-02607dd8e909414dab0430f9386be0fe
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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