Hydrazine hydrate (1:1) → HCID 178435605, compound

HRID 1296900Notes

Reaction equation

HRID 1296900 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:20](=O)[C:19]3[C:14](=[CH:15][C:16]([OH:24])=[C:17]([CH2:22][CH3:23])[CH:18]=3)[O:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].O.[NH2:26][NH2:27]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:20]([C:19]3[CH:18]=[C:17]([CH2:22][CH3:23])[C:16]([OH:24])=[CH:15][C:14]=3[OH:13])=[N:26][NH:27][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 589135643-(3,4-Dimethoxy-phenyl)-6-ethyl-7-hydroxy-chromen-4-one

Product 1

HCID 178435605HCID 178435605, compoundYield 61.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compounds was synthesised in the same manner as described above. 3-(3,4-Dimethoxy-phenyl)-6-ethyl-7-hydroxy-chromen-4-one (0.25 g, 0.77 mmol), hydrazine hydrate (4 ml), ethanol (10 ml). The crude solid product was columned to give 4-[4-(3,4-Dimethoxy-phenyl)-1H-pyrazol-3-yl]-6-ethyl-benzene-1,3-diol as a white solid (0.16 g, 61.1%); Rf 0.33 Cf SM 0.71 ethyl acetate/hexane (75/25).

Workup

  1. customThis compounds was synthesised in the same manner

Sources & evidence

ORD record
ord-f0d0e5d3858549b09ac5b52d39ddee2d
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

Loading…