Hydrazine hydrate (1:1) → HCID 178516580, compound

HRID 1296902Notes

Reaction equation

HRID 1296902 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17](=O)[C:16]3[C:11](=[CH:12][C:13]([OH:20])=[C:14]([Cl:19])[CH:15]=3)[O:10][CH:9]=2)=[CH:4][CH:3]=1.O.[NH2:22][NH2:23]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]([C:16]3[CH:15]=[C:14]([Cl:19])[C:13]([OH:20])=[CH:12][C:11]=3[OH:10])=[N:22][NH:23][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913628HCID 58913628, compound

Product 1

HCID 178516580HCID 178516580, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compounds was synthesised in the same manner as described above. 3-(4-Bromo-phenyl)-6-chloro-7-hydroxy-chromen-4-one (0.1 g, 0.28 mmol), hydrazine hydrate (4 ml), ethanol (10 ml). 4-[4-(4-Bromo-phenyl)-1H-pyrazol-3-yl]-6-chloro-benzene-1,3-diol precipitated out on quenching as a white solid (0.073 g, 71.2%); Rf 0.34 Cf SM 0.55 ethyl acetate/hexane (75/25).

Workup

  1. customThis compounds was synthesised in the same manner
  2. custom4-[4-(4-Bromo-phenyl)-1H-pyrazol-3-yl]-6-chloro-benzene-1,3-diol precipitated out
  3. customon quenching as a white solid (0.073 g, 71.2%)

Sources & evidence

ORD record
ord-c706b6be93214015a7c13e3269cac55b
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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