Hydrazine hydrate (1:1) → HCID 178488791, compound

HRID 1296903Notes

Reaction equation

HRID 1296903 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=1)[C:5]2=O.O.[NH2:25][NH2:26]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[C:6]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=3)=[CH:7][NH:26][N:25]=2)[C:9]([OH:8])=[CH:10][C:11]=1[OH:12]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913489HCID 58913489, compound

Product 1

HCID 178488791HCID 178488791, compoundYield 65.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compounds was synthesised in the same manner as described above. 6-Chloro-3-(3,4-dimethoxy-phenyl)-7-hydroxy-chromen-4-one (0.2 g, 0.62 mmol), hydrazine hydrate (4 ml), ethanol (10 ml). The crude solid product was columned to give 4-Chloro-6-[4-(3,4-dimethoxy-phenyl)-1H-pyrazol-3-yl]-benzene-1,3-diol as a white solid (0.139 g, 65.1%); Rf 0.36 Cf SM 0.56 ethyl acetate/hexane (75/25).

Workup

  1. customThis compounds was synthesised in the same manner

Sources & evidence

ORD record
ord-3cb4b2770d284b59ba98f47fc4016496
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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