Hydrazine hydrate (1:1) → HCID 178516579, compound

HRID 1296904Notes

Reaction equation

HRID 1296904 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]1[CH:22]=[CH:21][C:16]3[O:17][CH2:18][CH2:19][O:20][C:15]=3[CH:14]=1)[C:5]2=O.O.[NH2:25][NH2:26]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[C:6]([C:13]3[CH:22]=[CH:21][C:16]4[O:17][CH2:18][CH2:19][O:20][C:15]=4[CH:14]=3)=[CH:7][NH:26][N:25]=2)[C:9]([OH:8])=[CH:10][C:11]=1[OH:12]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913603HCID 58913603, compound

Product 1

HCID 178516579HCID 178516579, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compounds was synthesised in the same manner as described above. 6-Chloro-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-7-hydroxy-chromen-4-one (0.1 g, 0.30 mmol), hydrazine hydrate (4 ml), ethanol (10 ml). The quenched reaction was extracted into ethyl acetate (2×30 ml), washed (water), dried (MgSO4), and the solvent remove to give 4-Chloro-6-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-1H-pyrazol-3-yl]-benzene-1,3-diol as an off white solid (0.031 g, 30%); Rf 0.6 Cf SM 0.8 ethyl acetate/hexane (75/25).

Workup

  1. customThis compounds was synthesised in the same manner
  2. customThe quenched reaction
  3. extractionwas extracted into ethyl acetate (2×30 ml)
  4. washwashed (water)
  5. dry with materialdried (MgSO4)
  6. customthe solvent remove

Sources & evidence

ORD record
ord-9616786a0d6d40dba414d6becfd1bbb1
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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