Hydrazine hydrate (1:1) → HCID 178489324, compound

HRID 1296914Notes

Reaction equation

HRID 1296914 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20])[C:5]2=O.O.[NH2:23][NH2:24]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[C:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH3:20])=[CH:7][NH:24][N:23]=2)[C:9]([OH:8])=[CH:10][C:11]=1[OH:12]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913587HCID 58913587, compound

Product 1

HCID 178489324HCID 178489324, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compounds was synthesised in the same manner as described above. 6-Chloro-7-hydroxy-3-(2-methoxy-phenyl)-chromen-4-one (2.0 g, 6.6 mmol), hydrazine hydrate (5 ml), ethanol (10 ml). The quenched solution was extracted into ethyl acetate, washed (water), dried (MgSO4), and the solvent removed under vacuum to give 4-chloro-6-[4-(2-methoxy-phenyl)-1H-pyrazol-3-yl]-benzene-1,3-diol as a white solid. Rf 0.8 ethyl acetate/hexane (70/30).

Workup

  1. customThis compounds was synthesised in the same manner
  2. extractionThe quenched solution was extracted into ethyl acetate
  3. washwashed (water)
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-e37a66e64c534507bf9ef5d8aab9521b
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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