Hydrazine hydrate (1:1) → HCID 136049261, compound

HRID 1296919Notes

Reaction equation

HRID 1296919 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][C:7]([CH3:13])=[C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:5]2=O.O.[NH2:22][NH2:23]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[C:6]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[C:7]([CH3:13])[NH:23][N:22]=2)[C:9]([OH:8])=[CH:10][C:11]=1[OH:12]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913655HCID 58913655, compound

Product 1

HCID 136049261HCID 136049261, compoundYield 51.4%

Procedure

This compounds was synthesised in the same manner as described above. 6-Chloro-7-hydroxy-2-methyl-3-phenyl-chromen-4-one (0.5 g, 1.75 mmol), Hydrazine hydrate (5 ml). The quenched reaction was extracted into ethyl acetate, washed (water), dried (MgSO4), and the solvent removed under vacuum to give 4-Chloro-6-(5-methyl-4-phenyl-1H-pyrazol-3-yl)-benzene-1,3-diol as a white solid (0.27 g, 51.4%); Rf 0.55 ethyl acetate/hexane (80/20)].

Workup

  1. customThis compounds was synthesised in the same manner
  2. customThe quenched reaction
  3. extractionwas extracted into ethyl acetate
  4. washwashed (water)
  5. dry with materialdried (MgSO4)
  6. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-b1993813b5fe4e059bbb51f4f31074d0
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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