Hydrazine hydrate (1:1) → HCID 136049335, compound

HRID 1296920Notes

Reaction equation

HRID 1296920 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17](=O)[C:16]3[C:11](=[CH:12][C:13]([OH:20])=[C:14]([Cl:19])[CH:15]=3)[O:10][C:9]=2[CH3:21])=[CH:4][CH:3]=1.O.[NH2:23][NH2:24]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]([C:16]3[CH:15]=[C:14]([Cl:19])[C:13]([OH:20])=[CH:12][C:11]=3[OH:10])=[N:23][NH:24][C:9]=2[CH3:21])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913640HCID 58913640, compound

Product 1

HCID 136049335HCID 136049335, compound

Procedure

This compounds was synthesised in the same manner as described above. 3-(4-Bromo-phenyl)-6-chloro-7-hydroxy-2-methyl-chromen-4-one (0.5 g, 1.4 mmol), Hydrazine hydrate (5 ml). 4-[4-(4-Bromo-phenyl)-5-methyl-1H-pyrazol-3-yl]-6-chloro-benzene-1,3-diol precipitated out as a pale orange solid (0.08 g, 63.7%); Rf 0.48 cf SM 0.8 [ethyl acetate/petroleum ether 40–60° C. (80/20)].

Workup

  1. customThis compounds was synthesised in the same manner
  2. custom4-[4-(4-Bromo-phenyl)-5-methyl-1H-pyrazol-3-yl]-6-chloro-benzene-1,3-diol precipitated out as a pale orange solid (0.08 g, 63.7%)
  3. customcf SM 0.8 [ethyl acetate/petroleum ether 40–60° C. (80/20)]

Sources & evidence

ORD record
ord-7ba5c849745542c5836a9fbf121bb47f
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

Loading…