Hydrazine hydrate (1:1) → HCID 135425202, compound

HRID 1296922Notes

Reaction equation

HRID 1296922 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][C:7]([CH3:13])=[C:6]([C:14]1[CH:23]=[CH:22][C:17]3[O:18][CH2:19][CH2:20][O:21][C:16]=3[CH:15]=1)[C:5]2=O.O.[NH2:26][NH2:27]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[C:6]([C:14]3[CH:23]=[CH:22][C:17]4[O:18][CH2:19][CH2:20][O:21][C:16]=4[CH:15]=3)=[C:7]([CH3:13])[NH:27][N:26]=2)[C:9]([OH:8])=[CH:10][C:11]=1[OH:12]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913613HCID 58913613, compound

Product 1

HCID 135425202HCID 135425202, compoundYield 63.7%

Procedure

This compounds was synthesised in the same manner as described above. 6-Chloro-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-7-hydroxy-2-methyl-chromen-4-one (0.2 g, 0.58 mmol), Hydrazine hydrate (5 ml). The quenched reaction was extracted into ethyl acetate, washed (water), dried (MgSO4), and the solvent removed under vacuum to give 4-Chloro-6-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-benzene-1,3-diol as a white solid (0.08 g, 63.7%).

Workup

  1. customThis compounds was synthesised in the same manner
  2. customThe quenched reaction
  3. extractionwas extracted into ethyl acetate
  4. washwashed (water)
  5. dry with materialdried (MgSO4)
  6. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-1cca18f61f494224ab267eca9805482a
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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