Hydrazine hydrate (1:1) → HCID 178511053, compound

HRID 1296925Notes

Reaction equation

HRID 1296925 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]1[CH:24]=[CH:23][C:16]([O:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22])=[C:15]([O:25][CH2:26][CH2:27][CH2:28][C:29]#[N:30])[CH:14]=1)[C:5]2=O.O.[NH2:33][NH2:34]>>[Cl:1][C:2]1[C:11]([OH:12])=[CH:10][C:9]([OH:8])=[C:4]([C:5]2[C:6]([C:13]3[CH:24]=[CH:23][C:16]([O:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22])=[C:15]([O:25][CH2:26][CH2:27][CH2:28][C:29]#[N:30])[CH:14]=3)=[CH:7][NH:34][N:33]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913503HCID 58913503, compound

Product 1

HCID 178511053HCID 178511053, compoundYield 90.1%

Procedure

This compound was synthesised in the same manner as described above. 4-[4-(6-Chloro-7-hydroxy-4-oxo-4H-chromen-3-yl)-2-(3-cyano-propoxy)-phenoxy]-butyronitrile (0.12 g, 0.27 mmol), Hydrazine hydrate (5 ml). The precipitate formed on quenching was filtered to give 4-[4-[3-(5-Chloro-2,4-dihydroxy-phenyl)-1H-pyrazol-4-yl]-2-(3-cyano-propoxy)-phenoxy]-butyronitrile as a white solid (0.11 g, 90.1%); Rf 0.6 ethyl acetate/hexane (70/30)].

Workup

  1. customThis compound was synthesised in the same manner
  2. customThe precipitate formed
  3. customon quenching
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-bb40398247684d6f860b8df5277f4761
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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