反应详情

3-(4-Methoxy-phenyl)-2,8-dimethyl-4H-chromene-4,7-diol (1 eq) was taken up in a 1:1 solution of EtOH:Hydrazine hydrate and heated under microwave conditions (120° C., 300 sec). The solution was concentrated in vacuo, residue quenched with cold water, extracted with ethyl acetate and purified by flash chromatography (1% MeOH-DCM). The yellow oil was then triturated with ether:hexane to give 4-[4-(4-methoxy-phenyl)-5-methyl-1H-pyrazol-3-yl]-2-methyl-benzene-1,3-diol as a solid.

1. concentrationThe solution was concentrated in vacuo, residue
2. customquenched with cold water
3. extractionextracted with ethyl acetate
4. custompurified by flash chromatography (1% MeOH-DCM)
5. customThe yellow oil was then triturated with ether