Ammonium Acetate → 2-Cyanoethyl 3-aminocrotonate

HRID 1297018Notes

Reaction equation

[C:1]([O:7][CH2:8][CH2:9][C:10]#[N:11])(=[O:6])[CH2:2][C:3]([CH3:5])=O.C([O-])(=O)C.[NH4+:16]>>[NH2:16]/[C:3](/[CH3:5])=[CH:2]\[C:1]([O:7][CH2:8][CH2:9][C:10]#[N:11])=[O:6]

Participants

Reactant 2

HCID 517165Ammonium Acetate

HCID 123604062-Cyanoethyl 3-oxobutanoate

Product 1

HCID 136714102-Cyanoethyl 3-aminocrotonate

Procedure

Namely, 2-cyanoethyl acetoacetate (11) is reacted with an amine or ammonium acetate to obtain 2-cyanoethyl 3-aminocrotonate (35).

Sources & evidence

ORD record: ord-70ff34f3942b47d2b27a4986b8d5f35d
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07247645B2

Reaction notes

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