Hydrochloric Acid → 1,1-Diphenylbutane-1,4-diol

HRID 1297020ノート

反応式

HRID 1297020 の反応式
[C:1]1([Mg]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9]1(=[O:14])[O:13][CH2:12][CH2:11][CH2:10]1.[Cl-].[NH4+].Cl>C1COCC1>[C:1]1([C:9]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)([OH:14])[CH2:10][CH2:11][CH2:12][OH:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 7302Gamma-ButyrolactoneHCID 25517Ammonium ChlorideHCID 178418255HCID 178418255、化合物

生成物 1

HCID 966791,1-Diphenylbutane-1,4-diol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

60 ml (120 mmol) of 2 M solution of phenyl magnesium bromide in THF was added dropwise to 4.33 g (50.3 mmol) of γ-butyrolactone in 60 ml of THF for the duration of 50 minutes. After stirring at room temperature overnight, a saturated aqueous ammonium chloride solution and then 2 N hydrochloric acid were added dropwise to the reaction mixture. After the extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the title compound.

後処理

  1. extractionAfter the extraction with ethyl acetate
  2. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a1300b65ce05412092a24a55b6cd2266
出典データセット
uspto-grants-2007_07
特許番号
US07247645B2

反応ノート

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