2-Bromopyridine → 5-(2,4-dichlorophenyl)-N-[(3R,4S)-4-ethoxy-1-pyridin-2-ylpyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine
Reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([CH2:31][CH3:32])[C:12]([NH:17][C@H:18]2[C@@H:22]([O:23][CH2:24][CH3:25])[CH2:21][N:20]([C:26]3S[CH:28]=[CH:29][N:30]=3)[CH2:19]2)=[N:13][C:14]=1[CH2:15][CH3:16].Br[C:34]1[CH:39]=CC=CN=1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([CH2:31][CH3:32])[C:12]([NH:17][C@H:18]2[C@@H:22]([O:23][CH2:24][CH3:25])[CH2:21][N:20]([C:26]3[CH:39]=[CH:34][CH:28]=[CH:29][N:30]=3)[CH2:19]2)=[N:13][C:14]=1[CH2:15][CH3:16]Participants
3
Procedure
Following the procedure for the preparation of 5-(2,4-dichlorophenyl)-N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine but substituting 2-bromo pyridine provided the title compound as an amporphous solid: 1 H NMR (400 MHz, CDCl3) δ) 8.20, 7.50, 7.32, 7.28, 6.69, 6.53, 5.33, 4.92, 4.28, 4.05, 3.92–3.78, 3.58, 3.42, 2.73, 2.50, 1.33–1.25,1.16; HRMS (ESI) calcd for C25H29N5OCl2+H1 486.1827. found 486.1827.
Sources & evidence
- ORD record
- ord-785dac5092c14d8cbf32a662742855b7
- Source dataset
- uspto-grants-2007_07
- Patent number
- US07250418B2
Reaction notes
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