Skatole → 4-Chloro-1-methyl-1H-indole

HRID 1297412Notes

Reaction equation

HRID 1297412 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2.[CH3:11]C1C2C(=CC=CC=2)NC=1>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[CH3:11]

Participants

3

Reactant 2

HCID 6736SkatoleHCID 913454-Chloroindole

Product 1

HCID 130487594-Chloro-1-methyl-1H-indoleYield 100%

Procedure

According to the procedure of Preparation 13 (a), except substituting 4-chloroindole for the 3-methylindole, the title compound (2.2 g, 100%) was obtained as an amber oil: MS (ES) m/e 166.0 (M+H)+.

Sources & evidence

ORD record
ord-c438081b719b42a18b42cb7fb6d46354
Source dataset
uspto-grants-2007_07
Patent number
US07250424B2

Reaction notes

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