Hydrazine hydrate (1:1) → HCID 13504589, compound

HRID 129752Notes

Reaction equation

HRID 129752 reaction equation
[C:1]1([C:7]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[C:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][N:17]3C(=O)C4=CC=CC=C4C3=O)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[NH2:17][CH2:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][C:8](=[C:7]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19370249HCID 19370249, compound

Product 1

HCID 13504589HCID 13504589, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 900 mg (2.06 mmole) of 4-(diphenylmethylene)-1-(3-phthalimidopropyl)piperidine (prepared as described in Preparation 10'), 350 mg (7 mmole) of hydrazine hydrate and 20 ml of ethanol was heated under reflux for 2 hours. At the end of this time, the crystals which precipitated were filtered off and the solvent was removed from the filtrate by distillation under reduced pressure, to afford 460 mg (yield 73%) of the title compound as an oil.

Workup

  1. customprepared
  2. temperaturewas heated
  3. temperatureunder reflux for 2 hours
  4. customAt the end of this time, the crystals which precipitated
  5. filtrationwere filtered off
  6. customthe solvent was removed from the filtrate by distillation under reduced pressure

Sources & evidence

ORD record
ord-4c5990a71cc64fe8bbe5b0dcd8425758
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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