Benzhydrylpiperazine → HCID 19370347, compound

HRID 129757Notes

Reaction equation

HRID 129757 reaction equation
CS(O[CH2:6][CH2:7][N:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:9])(=O)=O.[C:15]1([CH:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:28]1([CH:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:22]2[CH2:23][CH2:24][N:25]([CH2:6][CH2:7][N:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:9])[CH2:26][CH2:27]2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 70048BenzhydrylpiperazineHCID 19370295HCID 19370295, compound

Product 1

HCID 19370347HCID 19370347, compoundYield 64.2%

Conditions

Temperature
80 °C

Procedure

A mixture of 0.23 g of 2-(N-ethoxycarbonyl-N-methylamino)ethyl methanesulfonate (prepared as described in Preparation 34') and 0.26 g of 4-diphenylmethylpiperazine was stirred at 80° C. for 5 hours. At the end of this time, the mixture was purified by column chromatography through silica gel, using a 20:1 by volume mixture of ethyl acetate and ethanol as the eluent, to give 0.25 g (yield 64%) of the title compound as an oil.

Workup

  1. customprepared
  2. customAt the end of this time, the mixture was purified by column chromatography through silica gel
  3. additionby volume mixture of ethyl acetate and ethanol as the eluent

Sources & evidence

ORD record
ord-63bdc58302294b288d9b64cf2f31e842
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

Loading…