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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1297600Generated: October 29, 2026

Ethylamine hydrochloride → 2-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-ethylcarbamoyl-1-methyl-ethyl)-benzyl]-nicotinamide

https://huagongshe.com/reaction/1297600

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthylamine hydrochlorideHCID 11198—
ReactantEthanaminideHCID 187872—
Reactant2-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-methyl-1-methylcarbamoyl-ethyl)-benzyl]-nicotinamideHCID 10114602—
Product2-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-ethylcarbamoyl-1-methyl-ethyl)-benzyl]-nicotinamideHCID 10226537—

Reaction Steps

The remaining portion of the tetrahydrofuran solution from Example 5a (10 mL) was converted to the ethyl amide with ethylamine hydrochloride using the same procedure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07250518B2
Source datasetuspto-grants-2007_07
ORD IDord-5f95505d68174f8797f4db0ccf53eee8
Source noteuspto-grants-2007_07