Ethylamine hydrochloride → 2-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-ethylcarbamoyl-1-methyl-ethyl)-benzyl]-nicotinamide

HRID 1297600Notes

Reaction equation

HRID 1297600 reaction equation
[CH2:1]([NH-])C.Cl.C(N)C.[O:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:17][C:18]3[N:40]=[CH:39][CH:38]=[CH:37][C:19]=3[C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([CH3:36])([C:32](=[O:35])[NH:33][CH3:34])[CH3:31])=[CH:26][CH:25]=3)=[O:21])=[CH:16][C:11]=2[O:10][CH2:9]1>>[O:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:17][C:18]3[N:40]=[CH:39][CH:38]=[CH:37][C:19]=3[C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([C:32](=[O:35])[NH:33][CH2:34][CH3:1])([CH3:36])[CH3:31])=[CH:26][CH:25]=3)=[O:21])=[CH:16][C:11]=2[O:10][CH2:9]1

Participants

4

Reactant 3

HCID 11198Ethylamine hydrochlorideHCID 187872EthanaminideHCID 101146022-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-methyl-1-methylcarbamoyl-ethyl)-benzyl]-nicotinamide

Product 1

HCID 102265372-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-ethylcarbamoyl-1-methyl-ethyl)-benzyl]-nicotinamide

Procedure

The remaining portion of the tetrahydrofuran solution from Example 5a (10 mL) was converted to the ethyl amide with ethylamine hydrochloride using the same procedure.

Sources & evidence

ORD record
ord-5f95505d68174f8797f4db0ccf53eee8
Source dataset
uspto-grants-2007_07
Patent number
US07250518B2

Reaction notes

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