反应详情

温度

240 °C

A mixture of 2-[(4-iodo-phenylamino)-methylene]-malonic acid diethyl ester (81 g, 0.21 mol) in diphenylether (60 mL) was refluxed at 240° C. for 14 h. After cooling, ethanol was added and the mixture was heated to reflux for 3 h. After cooling, the solid was collected by filtration, washed with hexane and dried to obtain 6-iodo-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (59 g, 83%) as a yellow solid.

1. temperatureAfter cooling
2. temperaturethe mixture was heated
3. temperatureto reflux for 3 h
4. temperatureAfter cooling
5. filtrationthe solid was collected by filtration
6. washwashed with hexane
7. customdried