Diisopropylethylamine → HCID 178516946, compound

HRID 1297614Notes

Reaction equation

[OH:1][CH2:2][C@H:3]([NH2:11])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[S:12]1[CH2:18][C:16](=[O:17])[NH:15][C:13]1=S.C(N(C(C)C)CC)(C)C>>[OH:1][CH2:2][CH:3]([NH:11][C:13]1[S:12][CH2:18][C:16](=[O:17])[N:15]=1)[CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

Reactant 3

HCID 81531Diisopropylethylamine

HCID 853475phenylalaninol, (R)-

HCID 1201546Rhodanine

Product 1

HCID 178516946HCID 178516946, compound

Procedure

Similar procedure as described in example 1f was used, starting (R)-1-hydroxymethyl-2-phenyl-ethylamine, rhodanine (2-thioxo-thiazolin-4-one) and DIEA (diisopropylethyl-amine) to give 2-(1-hydroxymethyl-2-phenyl-ethylamino)-thiazol-4-one. LC-MS m/e 251 (MH+).

Sources & evidence

ORD record: ord-6911cd4cf11b42dc9e70f2ab0dd79b79
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07250515B2

Reaction notes

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