反应详情

温度

100 °C

To the suspension of 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c) (14 g, 0.039 mol) in anhydrous ethanol (180 mL) was added sodium ethoxide (4.16 g, 0.07 mol). The mixture was heated to 100° C. under a pressure tube and stirred for 10 h. After cooling to room temperature, the ice water was added. The solid was collected by filtration, washed with water and dried to obtain 4-Ethoxy-6-iodo-quinoline-3-carbonitril (12 g, 92%) as a yellow solid. LC-MS m/e 325 (MH+).

1. temperatureAfter cooling to room temperature
2. filtrationThe solid was collected by filtration
3. washwashed with water
4. customdried