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Diisopropylethylamine → 4-ethoxy-6-[(Z)-[4-oxo-2-[[4-(trifluoromethyl)-2-pyridinyl]methylamino]-1,3-thiazol-5-ylidene]methyl]quinoline-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | [4-(Trifluoromethyl)pyridin-2-yl]methanamine | HCID 3682810 | — |
| 反応物 | 4-Ethoxy-6-[2-methylsulfanyl-4-oxo-4h-thiazol-(5z)-ylidenemethyl]-quinoline-3-carbonitrile | HCID 58585820 | — |
| 生成物 | 4-ethoxy-6-[(Z)-[4-oxo-2-[[4-(trifluoromethyl)-2-pyridinyl]methylamino]-1,3-thiazol-5-ylidene]methyl]quinoline-3-carbonitrile | HCID 178466946 | — |
反応手順
Similar procedure as described in example 14h was used, starting from 4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile (example 14g), 4-trifluoromethyl-pyridin-2-ylmethylamine and DIEA to give 4-ethoxy-6-[4-oxo-2-[(4-trifluoromethyl-pyridin-2-ylmethyl)-amino]-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile. LC-MS m/e 484 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07250515B2 |
| 出典データセット | uspto-grants-2007_07 |
| ORD ID | ord-4ada4d80906e4082b00c8fea9b90ec56 |
| 出典メモ | uspto-grants-2007_07 |